FOXO4-DRI 25 mg

The D-retro inverso (DRI)-isoform of FOXO4 is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging.


Foxo4-dri  Product Description


Our products are intended for laboratory research.

In contrast to Chinese alternatives, we purify our products of synthesis byproducts such as TFA salts.


Foxo4-dri  is a research compound which has been shown to be the world’s first senolytic peptide in Dutch mouse studies. At Canlab Research, we offer high quality Foxo4-dri for research purposes.



FOXO4 lives in the nucleus of the cell and p53 does its work at the mitochondrial level — two very different sites in the inside of a cell. At Breakthrough Labs we needed to find a way to get P53 and FOXO4 separated from one another so that p53 could do its work and eliminate the senescent cell from the inside. To do this another version of FOXO4 was created that had a Trojan horse effect ( it acted like FOXO4 from a chemical standpoint) . This molecule looked like FOXO4 to the cell, and it acted like it too, but this peptide called FOXO4-dri, didn’t only live in the nucleus — it could exist at any place inside the cell.


The p53 breaks away from FOXO4 when FOXO4-dri is introduced into the senescent cells. Because of this effect the cell can do it’s work and the cell can undergo apoptosis — it can finally commit suicide. Therefore, it does not hang around and signal harmful chemical messages to the other cells. This is what occurs in younger subjects, where this mechanism is at peak. Therefore, a senolytic virtually recreates a younger cellular environment. Once senescent cells are killed off, past a threshold level of them being toxic, healthy cells are allowed to flourish.



Thus, this compound has amazing implications. In animal studies using this substance, not only cellular function returned but systemic change occurred as well. Animals with organ damage, saw these traits reversed. Energy returned and physical activity increased. Similar results have been profiled in small-scale, preclinical human studies.


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